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T37496L

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  • 抑制剂&激动剂
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    TargetMol | Inhibitors_Agonists
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    TargetMol | Peptide_Products
  • Alamandine TFA
    T37496L
    Alamandine TFA 是肾素-血管紧张素系统 (RAS) 的成员,是一种血管活性肽,是 G 蛋白偶联受体 MrgD 的内源性配体。它通过抗高血压作用来保护肾脏和心脏。
    • ¥ 221
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    TargetMol | Inhibitor Sale
  • TargetMol
    Alamandine
    T374961176306-10-7
    Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.
    • ¥ 1538
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