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Gliotoxin

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  • 抑制剂&激动剂
    5
    TargetMol | Inhibitors_Agonists
  • 天然产物
    2
    TargetMol | Natural_Products
  • Gliotoxin
    胶霉毒素
    TN169467-99-2
    Gliotoxin 是一种次生代谢产物,由A. fumigatus 分泌,可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性,从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度,调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞。
    • 待估
    35日内发货
    规格
    数量
  • Gliotoxin-13C13
    Gliotoxin-13C13
    T35773
    Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils.4,5It suppresses viral infection by Nipah and Hendra virus in HEK293T cells (IC50s = 149 and 579 nM, respectively).6Under reducing conditions, gliotoxin inhibits leukotriene A4hydrolase epoxide hydrolase activity, but not aminopeptidase activity, and leukotriene B4synthesis in neutrophils and monocytes.7
    • 待估
    35日内发货
    规格
    数量
  • Bisdethiobis(methylthio)gliotoxin
    TN352074149-38-5
    Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
    • ¥ 3090
    期货
    规格
    数量
  • Gliotoxin monoacetate
    T70594146016-64-0
    Gliotoxin monoacetate is a toxin found in Aspergillus. It induces apoptosis in cervical cancer cells and chondrosarcoma cells, suppresses the adaptive immune response in leukocytes, and inhibits the proteasome in Plasmodium falciparum.
    • ¥ 10600
    6-8周
    规格
    数量
  • Makaluvamine A
    T70592146555-78-4
    Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors.
    • ¥ 13900
    8-10周
    规格
    数量