8-iso prostaglandin f1alpha

8-iso Prostaglandin F1α（8-异前列腺素 F1α）是一种由花生四烯酸产生的异前列腺素，能引起浓度依赖性的的血管收缩效应，包括肺动脉（PA）、肺静脉（PV）和肠系膜动脉（MA），通过TXA2R、酪氨酸激酶和Rho激酶的激活。

Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3]