7 dehydrocholesterol

7-Dehydrocholesterol (Provitamin D3) 是合成胆固醇和维生素 D3的前体。7-Dehydrocholesterol 下调培养的 Smith-Lemi-Opitz 综合征皮肤成纤维细胞中的胆固醇生物合成。

7-Dehydrocholesterol (Standard) 是一种可用于分析的标准物质，通常用作 7-Dehydrocholesterol 的研究和分析中参考的标准样品。7-Dehydrocholesterol (Provitamin D3) 是合成胆固醇和维生素 D3的前体。7-Dehydrocholesterol 下调培养的 Smith-Lemi-Opitz 综合征皮肤成纤维细胞中的胆固醇生物合成。

7-Dehydrocholesterol-[13C5] (Standard) 是 7-Dehydrocholesterol-[13C5] 的标准品，适用于定量分析、质量控制及生化实验等相关研究。

AY 9944 是特异性的胆固醇生物合成抑制剂。它抑制 7- 脱氢胆固醇 Δ7- 还原酶 (IC50:13 nM)，导致胆固醇不足和 7DHC 积累。在高剂量下，它可在培养的胚胎中抑制固醇 Δ7-Δ8 异构酶，造成胆固醇 8-en-3β-ol 的积累。

5-Dehydroepisterol 是⼀种具有抗真菌活性的甾醇衍⽣物，可经 C‑5 甾醇去饱和酶催化生成，并可在 7‑脱氢胆固醇还原酶作用下转化为 24‑亚甲基胆固醇。

Peraclopone is a hypolidemic drug. It is an inhibitor of 7-Dehydrocholesterol reductase. Peraclopone potently inhibits the final step in cholesterol biosynthesis. Feeding this agent to rats leads to a rapid replacement of membrane cholesterol with its immediate precursor 7-dehydrocholesterol, and a dramatic reduction in plasma sterol concentration. Peraclopone caused a dose-dependent decrease in cholesterol and a concomitant accumulation of provitamin D3 (7-dehydrocholesterol) in the skin, which is accompanied by an increase in the plasma level of 25-hydroxyvitamin D3. Treatment with peraclopone dramatically alters membrane sterol content in many membranes including the microvillus membrane of both the jejunum and ileum. In the jejunal microvillus membrane a major change in chemical composition occurred, presumably in response to the alteration in membrane sterol. The net result was a significant decline in both the static and dynamic component of membrane fluidity.

Boxidine inhibits the transformation of 7-dehydrocholesterol to cholesterol & also inhibits sterol absorption.

Pyrocholecalciferol 一种维生素 D 类似物，由 7-脱氢胆固醇 (7-DHC) 的光化学转化产生。

BM 15766 sulfate是一种7-脱氢胆固醇δ7-还原酶的抑制剂，具有降低血浆胆固醇水平的作用，属于降血脂剂类药物。