4-hydroxyphenylpyruvate dioxygenase

Nitisinone (SC0735) 是一种 4-羟基苯丙酮酸双加氧酶抑制剂。

Benzobicyclon(苯并双环酮)是一种 4-hydroxyphenylpyruvate dioxygenase (4-HPPD)抑制剂和除草剂，对一年生草、莎草和阔叶杂草具有光谱活性，而对水稻没有毒性。

Cypyrafluone, 作为一种4-羟基苯丙酮酸双加氧酶(4-HPPD)抑制剂，能有效阻止尿黑酸(HGA)的生成。

Iptriazopyrid (NC-656) 是一种作用于4-羟基苯丙酮酸双加氧酶 (HPPD) 的唑类羧酰胺除草剂，对拟南芥HPPD的Ki值为24.3 nM，对水稻HPPD的Ki值为33.3 nM。Iptriazopyrid 能阻断质体醌和类胡萝卜素的合成，导致杂草的黄化和死亡，预计在控制稻田杂草如稗草的研究中具有潜力。

HPPD-IN-5 (compound IV-45) 是一种 4-羟基苯基丙酮酸双加氧酶（HPPD）抑制剂，IC50值为 0.21 μM，并可作为除草剂使用。

Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (FAH) deficiency in mice when administered to pregnant dams.2It exhibits hepatoprotective effects inFAH-/-mice, such as prevention of increases in plasma levels of aspartate serine aminotransferase (AST) and conjugated bilirubin, when administration is continued following birth at a dose of 1 mg/kg. Nitisinone (100 μg) decreases urinary excretion of homogentisate and increases urinary excretion of HPPA, HPLA, and 4-hydroxyphenylacetate in a mouse model of alkaptonuria induced by ethylnitrosourea.3Formulations containing nitisinone have been used in the treatment of hereditary tyrosinemia type 1 (HT-1). 1.Ellis, M.K., Whitfield, A.C., Gowans, L.A., et al.Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dioneToxicol. Appl. Pharmacol.133(1)12-19(1995) 2.Grompe, M., Lindstedt, S., al-Dhalimy, M., et al.Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type INat. Genet.10(4)453-460(1995) 3.Suzuki, Y., Oda, K., Yoshikawa, Y., et al.A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuriaJ. Hum. Genet.44(2)79-84(1999)

Topramezone为高效的4-羟基苯基丙酮酸双加氧酶(4-HPPD)抑制剂，作为除草剂(herbicide)，适用于防治玉米中的阔叶杂草和禾本科杂草出苗后。

Fenquinotrione为4-羟基苯丙酮酸双加氧酶(HPPD)抑制剂，水稻HPPD (OsHPPD) 及拟南芥HPPD (AtHPPD) 的IC50分别达27.2及44.7nM。此化合物作为除草剂，对多种阔叶及芦苇杂草具有广泛防治效果，并展现出对水稻的高选择性。

HPPD-IN-3（compound 25） 是一种有效的 4-羟苯基丙酮酸双加氧酶（HPPD）抑制剂，其 IC50 值为 10 nM，比 Mesotrione 更具效能。

Topramezone (Standard) 是 Topramezone 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Topramezone为高效的4-羟基苯基丙酮酸双加氧酶(4-HPPD)抑制剂，作为除草剂(herbicide)，适用于防治玉米中的阔叶杂草和禾本科杂草出苗后。

Nitisinone-13C6 (Standard) 是 Nitisinone-13C6 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Nitisinone-13C6 用于通过气相色谱-质谱法或液相色谱-质谱法对尼替西酮进行定量分析时作为内标物。Nitisinone是一种 4-羟基苯丙酮酸双加氧酶（HPPD）的抑制剂，它在酪氨酸分解途径中将 4-羟基苯丙酮酸（HPPA）转化为同型儿茶酚酸。