2,3-Dehydro-3,4-dihydroivermectin is an analog of ivermectin and an anthelmintic. 2,3-Dehydro-3,4-dihydroivermectin has activity against L. amazonensis promastigotes and amastigotes ( IC 50 s=13.8 and 3.6 μM, respectively) without inducing cytotoxicity to macrophages ( IC 50 = 65.5 μM).