151988-33-9

Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue.

Ac2-26是一种Annexin A1的模拟肽，能够通过抑制p38MAPK NF-κB减轻糖尿病小鼠模型的肾脏炎症损伤，还能够通过LXA4 PI3K AKT信号通路抑制脓毒症诱导的心肌细胞凋亡，以及通过调节IL-22 IL-22R1 STAT3信号通路减轻小鼠肝缺血再灌注损伤。