τ-fluvalinate

τ-Fluvalinate is a pyrethroid acaricide.1It induces tail currents in Western honeybee (A. mellifera) voltage-gated sodium channels (AmNav1) expressed inXenopusoocytes (EC50= 60 nM). It also induces tail currents in honeybee parasitic Varroa mite (V. destructor) Nav1 channels (VdNav1) expressed inXenopusoocytes (EC50= 160 nM) with a faster tail current decay than that of AmNav1 channels. Topical application of τ-fluvalinate (2 μl) in combination with coumaphos , atrazine , 2,4-DMPF, chlorpyrifos , and chlorothalonil does not affect honeybee queen mass, egg-laying patterns, or the mass of daughter worker bees at emergence.2Formulations containing τ-fluvalinate have been used to control Varroa mites in beehives. 1.Gosselin-Badaroudine, P., and Chahine, M.Biophysical characterization of the Varroa destructor NaV1 sodium channel and its affinity for τ-fluvalinate insecticideFASEB J.31(7)3066-3071(2017) 2.McAfee, A.Honey bee queen health is unaffected by contact exposure to pesticides commonly found in beeswaxSci. Rep.11(1)15151(2021)

τ-Fluvalinate（标准品）是τ-Fluvalinate的标准物质，适用于生化实验中的定量分析、质量控制及相关研究。τ-氟伐沙星是一种拟除虫菊酯类杀螨剂。其可在转染于非洲蜜蜂卵母细胞的西方蜜蜂电压门控钠通道（AmNav1）中诱导尾电流（EC50=60 nM）。该物质同样能在转染于蟾蜍卵母细胞的蜜蜂寄生螨（瓦螨）Nav1通道（VdNav1）中诱导尾电流（EC50=160 nM），且其尾电流衰减速率快于AmNav1通道。将τ-Fluvalinate（2 μl）与库马福、阿特拉津、2,4-DMPF、氯吡脲和氯溴异氰尿酸联合外用，不会影响蜜蜂蜂王体重、产卵模式或新工蜂的体重。含有τ-Fluvalinate的制剂已被用于控制蜂箱中的瓦螨。

Fluvalinate is a synthetic chemical compound and can be commonly used to control varroa mites in honey bee colonies.