β defensin 3 (human) (trifluoroacetate salt)

β-Defensin-3 (human) trifluoroacetate salt (hBD-3)是一种人体先天免疫核心抗菌肽，具有广谱杀菌、免疫调节、组织修复等活性。可用于皮肤病、癌症治疗及抗药性细菌感染研究。

Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd = 55.7 nM) and inhibits focus formation in Madin-Darby canine kidney (MDCK) cells infected with influenza A virus (IAV).