3-Butenoicacid, also known as Vinylacetic acid, is utilized in the synthesis of 3,6-dihydro-1,2-oxazine that possesses a bicyclic structure. This strained bicyclic compound, when combined with an external alkene, acts as a reactive substrate in domino metathesis reactions.
AM-9635 is a potent and selective PI3Kδ inhibitor. AM-9635 showes good cellular potency (in vitro pAKT IC50 = 4.2 nM ). AM-96352 inhibits KLH-specific IgG and IgM in a dosedependent manner AM-9635 is well tolerated at all doses and exhibits significantly reduced IgG and IgM specific antibodies . PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.