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Transthyretin Protein, Human, Recombinant (His)

产品编号 TMPY-01756

别名: PALB, HEL111, CTS, transthyretin, CTS1, HsT2651, TBPA

Transthyretin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is E9KL36.

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Transthyretin Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		现货
200 μg	￥ 6,750		5日内发货
500 μg	￥ 14,280		5日内发货

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参考文献

生物活性	Measured by its binding ability in a functional ELISA. Immobilized recombinant human TTR-His can bind recombinant Canine RBP4-Fc with a linear range of 0.3-10.0 μg/ml.
产品描述	Transthyretin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is E9KL36.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	E9KL36
别名	PALB, HEL111, CTS, transthyretin, CTS1, HsT2651, TBPA
蛋白构建	Human TTR (NP_000362.1) (Met 1-Glu 147) with a C-terminal polyhistidine tag
蛋白纯度	> 97 % as determined by SDS-PAGE
分子量	15.2 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Prealbumin/Transthyretin, also known as ATTR, Prealbumin, TTR and PALB, is a secreted and cytoplasm protein that belongs to the Prealbumin / Transthyretin family. Prealbumin / Transthyretin is detected in serum and cerebrospinal fluid (at protein level). It is highly expressed in choroid plexus epithelial cells. It is also detected in retina pigment epithelium and liver. Each monomer of Prealbumin / Transthyretin has two 4-stranded beta sheets and the shape of a prolate ellipsoid. Antiparallel beta-sheet interactions link monomers into dimers. A short loop from each monomer forms the main dimer-dimer interaction. These two pairs of loops separate the opposed, convex beta-sheets of the dimers to form an internal channel. Prealbumin/Transthyretin is a carrier protein. It transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. Defects in Prealbumin / Transthyretin are the cause of amyloidosis type 1 (AMYL1) which is a hereditary generalized amyloidosis due to Prealbumin / Transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.

参考文献

1. Westermark P,et al.(1990) Fibril in senile systemic amyloidosis is derived from normal transthyretin. Proc Natl Acad Sci U S A. 87(7): 2843-5. 2. Colon W,et al.(1992) Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro. Biochemistry. 31(36): 8654-60. 3. HAmmarstrm P,et al.(2003) Prevention of transthyretin amyloid disease by changing protein misfolding energetics. Science. 299(5607): 713-6.

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Keywords

Transthyretin Protein, Human, Recombinant (His) CTS-1 PALB HEL111 CTS CTS 1 transthyretin HEL 111 HsT 2651 HsT-2651 CTS1 HEL-111 HsT2651 TBPA recombinant recombinant-proteins proteins protein

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