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TFF1 Protein, Human, Recombinant (6xHis)

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产品编号 TMPY-05431U

TFF1 Protein, Human, Recombinant (6xHis) is expressed in HEK293 Cells. The accession number is P04155.

TFF1 Protein, Human, Recombinant (6xHis)

一键复制产品信息

产品编号 TMPY-05431U

TFF1 Protein, Human, Recombinant (6xHis) is expressed in HEK293 Cells. The accession number is P04155.

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产品信息

生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
产品描述	TFF1 Protein, Human, Recombinant (6xHis) is expressed in HEK293 Cells. The accession number is P04155.
种属	Human
表达系统	HEK293 Cells
标签	C-6xHis
蛋白编号	P04155
别名	trefoil factor 1,pS2,pNR-2,HPS2,HP1.A,D21S21,BCEI
蛋白构建	Glu25-Phe84
蛋白纯度	> 95% as determined by SDS-PAGE
分子量	7.5 kDa (Predicted); 14 kDa (Reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Trefoil Factor 1 (TFF1) belongs to the three structurally related secreted proteins that contain trefoil domains. TFF1 is an approximately 7 kDa peptide that plays an important role in epithelial regeneration and wound healing. It is highly expressed in goblet cells of the gastric and intestinal mucosa and by conjunctival goblet cells. By conserving intrachain disulfide bonds, human TFF1 formed a three-leaved conformation held together.It is a copper-binding protein that can form disulfide-linked homodimers, associate into disulfide-linked complexes with Gastrokine 2, and form non-covalent complexes with the mucin MUC5AC. TFF1 is down-regulated during the progression from gastritis to gastric dysplasia to gastric cancer, although it is up-regulated in breast and prostate cancers.