SIRP alpha Protein, Mouse, Recombinant (aa 32-373, hFc)

SIRP alpha Protein, Mouse, Recombinant (aa 32-373, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 115-125 KDa and the accession number is Q6P6I8.

规格	价格/CNY		数量
10 μg	￥ 740	5日内发货
50 μg	￥ 1,970	5日内发货
500 μg	￥ 12,100	5日内发货
1 mg	￥ 17,400	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 740

5日内发货

50 μg

￥ 1,970

5日内发货

500 μg

￥ 12,100

5日内发货

1 mg

￥ 17,400

5日内发货

产品描述	SIRP alpha Protein, Mouse, Recombinant (aa 32-373, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 115-125 KDa and the accession number is Q6P6I8.

种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q6P6I8
别名	SIRPA, SHPS1, Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, MFR, Signal-Regulatory Protein α-1, Signal-Regulatory Protein Alpha-1, SIRP, CD172a, CD172 Antigen-Like Family Member A
氨基酸序列	Lys32-Asn373
蛋白构建	Lys32-Asn373
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	115-125 KDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Mouse Signal Regulatory Protein α (SIRPα) is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation

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SIRP alpha Protein, Mouse, Recombinant (aa 32-373, hFc)

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