SIGIRR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.29 kDa and the accession number is Q6IA17-1.

Human

HEK293 Cells

TIR8,single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Met1-His118

> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC

Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Structurally, it is characterized by a single extracellular Ig domain, an intracellular TIR domain and 95-aa cytoplasmic tail. Recently, TIR8 was shown to inhibit NF-_x005f_x0001_B activation by members of the IL-1/TLR family. The inhibitory activity of TIR8 was associated with trapping of TRAF6 and IRAK1.