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PRLR Protein, Mouse, Recombinant (hFc)

PRLR Protein, Mouse, Recombinant (hFc)

产品编号 TMPJ-00346
别名: Prolactin R, Prlr, Prolactin receptor, PRL-R

PRLR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 62-88 KDa and the accession number is Q08501.

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PRLR Protein, Mouse, Recombinant (hFc)
规格 价格/CNY 货期 数量
10 μg ¥ 580 5日内发货
50 μg ¥ 1,410 5日内发货
500 μg ¥ 9,960 5日内发货
1 mg ¥ 14,200 5日内发货
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产品目录号及名称: PRLR Protein, Mouse, Recombinant (hFc) (TMPJ-00346)
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产品描述 PRLR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 62-88 KDa and the accession number is Q08501.
种属 Mouse
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 Q08501
别名 Prolactin R, Prlr, Prolactin receptor, PRL-R
氨基酸序列 Gln20-Asp229
蛋白构建 Gln20-Asp229
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 62-88 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 The prolactin receptor (PRLR) is a member of the class I cytokine/lactogen receptor family which mediates the diverse cellular actions of prolactin in several tissues. PRLRs are expressed in normal and neoplastic human breast tissue, and in most breast cancer cells. PRLR contains an extracellular region that binds prolactin, a transmembrane region, and a cytoplasmatic region required for the activation of the Jak2–Stat5 signal transduction pathway by Prl which is essential for transcriptional activation of all known prolactin regulated genes. PRLRs have also been observed in ovarian follicular cells of mice, pigs, sheep, deer, and humans, as well as in luteal tissue in cow and horse ovaries. Furthermore, PRLR knockout mice exhibit failure of embryonic implantation, reduced number of mature oocytes, and low fertilization rates. Knockout females also display a reduced number of primary follicles.

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Keywords

PRLR Protein, Mouse, Recombinant (hFc) Prolactin R Prlr Prolactin receptor PRL-R recombinant recombinant-proteins proteins protein

 

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