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SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)

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产品编号 TMPK-01352

The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 38.6 kDa and the accession number is P0C6U8.

SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)

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产品编号 TMPK-01352

规格	价格	库存
5 μg	¥ 193	6-8日内发货
10 μg	¥ 293	6-8日内发货
20 μg	¥ 463	5日内发货
50 μg	¥ 885	5日内发货
100 μg	¥ 1,470	5日内发货
200 μg	¥ 2,660	5日内发货
500 μg	¥ 5,930	5日内发货

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产品信息

生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
产品描述	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 38.6 kDa and the accession number is P0C6U8.
种属	SARS
表达系统	E. coli
标签	N-His-Avi
蛋白编号	P0C6U8
别名	Replicase polyprotein 1a,pp1a,PL-PRO,Plpro,PL2-PRO,Papain-like Protease,nsp1
蛋白构建	Glu1-Ile314
蛋白纯度	> 95% as determined by Tris-Bis PAGE
分子量	38.6 kDa (predicted) same as Tris-Bis PAGE result.
内毒素	< 1 EU/μg by the LAL method.
蛋白性状	Solution
缓冲液	Supplied as 0.22 μm filtered solution in 20 mM Tris, 100 mM NaCl, 10% Glycerol (pH 7.8).
存储	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses.