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顶部产品介绍化学信息储存和溶解信息计算器技术支持

Notch 2 Protein, Human, Recombinant (His & Avi)

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货号 TMPK-00465

别名 Notch-2, NOTCH2, N2ECD, N2, HJCYS, AGS2

Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch 2 is lethal, showing that not all functions overlap.Notch 2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

Notch 2 Protein, Human, Recombinant (His & Avi)
其他形式的 “Notch 2 Protein, Human, Recombinant (His & Avi)”:
Notch 2 Protein, Human, Recombinant (His & Avi), Biotinylated
N-2 Supplement (100X), Serum-free
Notch 2 Protein, Human, Recombinant (His)

Notch 2 Protein, Human, Recombinant (His & Avi)

一键复制产品信息
Rating icon 还可以
SPR兼容缓冲液
货号 TMPK-00465 别名 Notch-2, NOTCH2, N2ECD, N2, HJCYS, AGS2

Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch 2 is lethal, showing that not all functions overlap.Notch 2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

规格价格库存数量
5 μg
¥ 193
6-8日内发货
10 μg
¥ 293
6-8日内发货
20 μg
¥ 463
5日内发货
50 μg
¥ 885
5日内发货
100 μg
¥ 1,470
5日内发货
200 μg
¥ 2,660
5日内发货
500 μg
¥ 5,930
5日内发货
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产品介绍

生物活性
产品描述
Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch 2 is lethal, showing that not all functions overlap.Notch 2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
生物活性
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景
Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch 2 is lethal, showing that not all functions overlap.Notch 2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
种属
Human
表达系统
HEK293 Cells
标签C-His-Avi
蛋白编号Q04721
蛋白构建Leu26-GIn530
蛋白纯度
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
蛋白性状Solution
缓冲液Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
别名Notch-2, NOTCH2, N2ECD, N2, HJCYS, AGS2
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量57 kDa (predicted). Due to glycosylation, the protein migrates to 68-78 kDa based on Tris-Bis PAGE result.
储存&溶解度
运输方式In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
存储

计算器

  • 复溶 计算器
  • 重组蛋白稀释 计算器
  • 比活力 计算器

剂量转换

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技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.

关键词

NOTCH 2N-2N 2AGS-2AGS 2
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