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Noggin/NOG Protein, Human, Recombinant (CHO, hFc)

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产品编号 TMPY-00890U

Noggin/NOG Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q13253.

Noggin/NOG Protein, Human, Recombinant (CHO, hFc)

一键复制产品信息

产品编号 TMPY-00890U

Noggin/NOG Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q13253.

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产品信息

生物活性	ED 50 < 60.0 ng/ml, measured in a bioassay using ATDC5 cells in the presence of 10.0 ng/ml human BMP-4.
产品描述	Noggin/NOG Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q13253.
种属	Human
表达系统	CHO Cells
标签	C-hFc
蛋白编号	Q13253
蛋白构建	Gln28-Cys232
蛋白纯度	> 97% as determined by SDS-PAGE
分子量	57 kDa (Reducing conditions)
内毒素	< 0.2 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from 0.2 μm filtered solution in PBS.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Noggin, also known as NOG, is a homodimeric glycoprotein that bindsto and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors. Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients, regulating cellular responses dependent on the local concentration of the signaling molecule.