M-CSFR/CSF1R/CD115 Protein, Cynomolgus, Recombinant (His)

CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.

规格	价格/CNY		数量
100 μg	￥ 2,360	5日内发货
500 μg	￥ 9,490	5日内发货
1 mg	￥ 15,800	5日内发货

规格

价格/CNY

货期

数量

100 μg

￥ 2,360

5日内发货

500 μg

￥ 9,490

5日内发货

1 mg

￥ 15,800

5日内发货

生物活性

1. Immobilized Cynomolgus M-CSF R, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 17.6ng/ml determined by ELISA (QC Test). 2. Cynomolgus M-CSF R, His Tag immobilized on CM5 Chip can bind Cynomolgus M-CSF, His Tag with an affinity constant of 0.889 μM as determined in SPR assay.

产品描述

种属	Cynomolgus
表达系统	HEK293
标签	C-His
蛋白编号	G7P8P1
别名	M-CSF R, M-CSFR, HDLS, C-FMS, CSF1R, CSFR, CD115, MCSFR, FMS, CSF-1-R, FIM2, FMSFIM2
蛋白构建	Recombinant Cynomolgus M-CSF R/CSF1R/CD115 Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ile99-Pro596.[Accession \|G7P8P1]
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	The protein has a predicted MW of 56.3 kDa. Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.

内毒素	Less than 1EU per μg by the LAL method.
缓冲液	Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
复溶方法	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
存储	-20 to -80°C for 12 months as supplied from date of receipt. -20 to -80°C for 3-6 months in unopened state after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.