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LILRA3/CD85e Protein, Human, Recombinant (hFc)

产品编号 TMPY-03110

别名: ILT-6, HM43, HM31, LIR4, CD85e, LIR-4, leukocyte immunoglobulin like receptor A3, ILT6

LILRA3/CD85e Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 72 kDa and the accession number is AH28208.1.

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LILRA3/CD85e Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货
1 mg	￥ 29,100		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	LILRA3/CD85e Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 72 kDa and the accession number is AH28208.1.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	AH28208.1
别名	ILT-6, HM43, HM31, LIR4, CD85e, LIR-4, leukocyte immunoglobulin like receptor A3, ILT6
蛋白构建	The Human LILRA3 (AAH28208.1) (Met1-Glu439) was expressed, fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 80 % as determined by SDS-PAGE
分子量	72 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	ILT6, also known as LILRA3, belongs to the ILT family. In humans, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immunoglobulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

参考文献

1. Wi?niewski A,et al.(2004) Distribution of LILRA3 (ILT6 / LILRA3/LIR4) deletion in psoriatic patients and healthy controls. Hum Immunol. 64(4):458-61. 2. Norman PJ,et al.(2003) DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3. Immunogenetics. 55(3):165-71. 3. Cella M,et al.(1997) A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med. 185(10): 1743-51.

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Keywords

LILRA3/CD85e Protein, Human, Recombinant (hFc) LIR 4 ILT-6 HM-43 HM43 HM31 LIR4 HM 43 CD85e HM-31 ILT 6 LIR-4 leukocyte immunoglobulin like receptor A3 ILT6 HM 31 recombinant recombinant-proteins proteins protein

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