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IL-20 Protein, Human, Recombinant

产品编号 TMPY-02959

别名: ZCYTO10, interleukin-20, IL10D, 白细胞介素, interleukin 20, 白介素, IL-20

IL-20 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.7 kDa and the accession number is Q9NYY1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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IL-20 Protein, Human, Recombinant

规格	价格/CNY		货期	数量
20 μg	￥ 1,750		现货
100 μg	￥ 4,430		5日内发货
200 μg	￥ 7,790		5日内发货

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参考文献

生物活性	Measured in a cell proliferation assay using BaF3 mouse pro-B cells transfected with human IL20 Rα and human IL20 Rβ. The ED50 for this effect is typically 0.25-2.5 ng/mL.
产品描述	IL-20 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.7 kDa and the accession number is Q9NYY1.

种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	Q9NYY1
别名	ZCYTO10, interleukin-20, IL10D, 白细胞介素, interleukin 20, 白介素, IL-20
蛋白构建	The mature form of Human IL20 (Q9NYY1) (Leu25-Glu176) was expressed, with a N-terminal Met.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	17.7 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IL20/Interleukin-20 belongs to the IL-10 family. It is a cytokine structurally related to interleukin 10. IL20/Interleukin-20 can be detected in skin, trachea, and other tissues. It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. It has been shown that interleukin-20 transduces its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. It may be involved in epidermal function and psoriasis. It also regulates the proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. Also, IL20/Interleukin-20 also causes cell expansion of multipotential hematopoietic progenitor cells. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

参考文献

1. Chen XY, et al. (2011) The association between the IL-20-1723CG allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population. Dermatology. 222(1):24-30. 2. Baird AM, et al. (2011) IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. Eur J Cancer. 47(12):1908-18. 3. Logsdon NJ, et al. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 68(Pt 1):89-92.

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Keywords

IL-20 Protein, Human, Recombinant ZCYTO-10 IL20 IL 20 ZCYTO10 interleukin-20 IL10D ZCYTO 10 白细胞介素 interleukin 20 白介素 IL-20 recombinant recombinant-proteins proteins protein

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