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IL-1 alpha/IL-1A Protein, Rat, Recombinant

产品编号 TMPY-05836

别名: interleukin 1, alpha, IL-1 α/IL1A, interleukin 1, α

IL-1 alpha/IL-1A Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.80 kDa and the accession number is P16598.

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IL-1 alpha/IL-1A Protein, Rat, Recombinant

规格	价格/CNY		货期	数量
50 μg	￥ 3,430		5日内发货

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生物活性	Testing in progress
产品描述	IL-1 alpha/IL-1A Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.80 kDa and the accession number is P16598.

种属	Rat
表达系统	E. coli
标签	Tag Free
蛋白编号	P16598
别名	interleukin 1, alpha, IL-1 α/IL1A, interleukin 1, α
蛋白构建	Rat IL1A (NP_058715.1) (Ser115-Ser270)
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	17.80 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6, and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Nicklin MJ,et al.(1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4. 2. March CJ,et al.(1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7. 3. Bankers-Fulbright JL,et al.(1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83. 4. Dinarello CA,et al.(1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.

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Keywords

IL-1 alpha/IL-1A Protein, Rat, Recombinant interleukin 1, alpha IL-1 α/IL1A interleukin 1, α recombinant recombinant-proteins proteins protein

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