IL-15RA & IL-15 Protein, Human, Recombinant (hFc)

IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.

规格	价格/CNY		数量
10 μg	￥ 810	现货
20 μg	￥ 1,320	5日内发货
50 μg	￥ 2,470	5日内发货
100 μg	￥ 4,010	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 810

现货

20 μg

￥ 1,320

5日内发货

50 μg

￥ 2,470

5日内发货

100 μg

￥ 4,010

5日内发货

生物活性

TargetMol Bioactive

产品描述

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q13261&P40933
别名	IL-15 Receptor α & IL-15 Fusion Protein, Interleukin-15, IL15RA&IL15 Complex, IL-15 Receptor alpha & IL-15 Fusion Protein, IL-15, IL15, IL15RA&IL15
氨基酸序列	Ile31-Asp96&Asn49-Ser162(Asn120Asp)
蛋白构建	Ile31-Asp96&Asn49-Ser162(Asn120Asp)
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 8% Trehalose, 4% Mannitol, 0.02% Tween 80 (w/v), pH 7.5.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.

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Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

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IL-15RA & IL-15 Protein, Human, Recombinant (hFc)

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