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IL-28B Protein, Mouse, Recombinant (His)

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产品编号 TMPY-00454

IL-28B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.1 kDa and the accession number is Q8CGK6.

IL-28B Protein, Mouse, Recombinant (His)

一键复制产品信息

产品编号 TMPY-00454

IL-28B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.1 kDa and the accession number is Q8CGK6.

规格	价格	库存
5 μg	¥ 458	6-8日内发货
10 μg	¥ 747	6-8日内发货
20 μg	¥ 1,230	5日内发货
50 μg	¥ 2,440	5日内发货
100 μg	¥ 3,970	5日内发货
200 μg	¥ 6,820	5日内发货
500 μg	¥ 13,300	5日内发货
1 mg	¥ 25,900	5日内发货

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TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品信息

生物活性	Measured in antiviral assay using HepG2 cells infected with vesicular stomatitis virus. The ED50 for this effect is typically 44.6-178.4 ng/mL.
产品描述	IL-28B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.1 kDa and the accession number is Q8CGK6.
种属	Mouse
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q8CGK6
别名	interferon, λ3,interferon, lambda 3,INF-λ,INF-α,INF-lambda,INF-alpha,IL-28B,Il28b,Il28,IFL-1
蛋白构建	A DNA sequence encoding the mouse Ifnl3 (NP_796370.1) (Met1-Val193) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Asp 20
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	21.1 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFNλ) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, can increase the percentage of splenic CD8+ T cells in vaccinated animals and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.