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IL-18BP Protein, Human, Recombinant (His)

IL-18BP Protein, Human, Recombinant (His)

产品编号 TMPY-00846
别名: interleukin 18 binding protein, IL18BPa

IL-18BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is A0A024R5G2.

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IL-18BP Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 1,750 现货
200 μg ¥ 3,080 5日内发货
500 μg ¥ 6,540 5日内发货
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产品目录号及名称: IL-18BP Protein, Human, Recombinant (His) (TMPY-00846)
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生物活性
技术参数
产品性质
参考文献
生物活性 1. Measured by its ability to bind biotinylated Cynomolgus IL18 in functional ELISA. 2. Measured by its ability to inhibit the IL-18-induced response of KG‑1 human acute myelogenous leukemia cells. The ED50 for this effect is 0.05-0.35μg/mL in the presence of 50 ng/mL of recombinant human IL-18.

TargetMol Bioactive

产品描述 IL-18BP Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19 kDa and the accession number is A0A024R5G2.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 A0A024R5G2
别名 interleukin 18 binding protein, IL18BPa
蛋白构建 The Human IL18BPa (NP_001034748.1) (Met1-Gly194) was expressed with the polyhistidine tag at the C-terminus.
蛋白纯度 > 85 % as determined by SDS-PAGE

TargetMol

分子量 19 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

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Keywords

IL-18BP Protein, Human, Recombinant (His) interleukin 18 binding protein IL18BPa recombinant recombinant-proteins proteins protein

 

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