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IL-18BP Protein, Human, Recombinant (aa 1-192, hFc)

IL-18BP Protein, Human, Recombinant (aa 1-192, hFc)

产品编号 TMPY-05492
别名: interleukin 18 binding protein, IL18BPa

IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is AAD17187.1.

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IL-18BP Protein, Human, Recombinant (aa 1-192, hFc)
规格 价格/CNY 货期 数量
100 μg ¥ 1,750 现货
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产品目录号及名称: IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) (TMPY-05492)
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生物活性
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参考文献
生物活性 Measured by its ability to inhibit the IL-18-induced response of KG‑1 human acute myelogenous leukemia cells. The ED50 for this effect is 0.1‑0.6 µg/mL in the presence of 50 ng/mL of recombinant human IL-18.

TargetMol Bioactive

产品描述 IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is AAD17187.1.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 AAD17187.1
别名 interleukin 18 binding protein, IL18BPa
蛋白构建 The Human IL18BP (AAD17187.1) (Met1-Gly192) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度 > 95 % as determined by SDS-PAGE.

TargetMol

分子量 44.4 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

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Keywords

IL-18BP Protein, Human, Recombinant (aa 1-192, hFc) interleukin 18 binding protein IL18BPa recombinant recombinant-proteins proteins protein

 

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