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IL-17 Protein, Rhesus, Recombinant

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产品编号 TMPY-04710

IL-17 Protein, Rhesus, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 15.1 kDa and the accession number is A0A8J8YJF1.

IL-17 Protein, Rhesus, Recombinant

一键复制产品信息

产品编号 TMPY-04710

IL-17 Protein, Rhesus, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 15.1 kDa and the accession number is A0A8J8YJF1.

规格	价格	库存
5 μg	¥ 497	6-8日内发货
10 μg	¥ 816	6-8日内发货
20 μg	¥ 1,350	5日内发货
50 μg	¥ 2,480	5日内发货
100 μg	¥ 4,550	5日内发货

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产品信息

生物活性	1.Measured by its binding ability in a functional ELISA. 2. Immobilized rhesus IL17a at 10μg/mL (100μL/well) can bind rhesus IL17RA-Fc , the EC50 of rhesus IL17RA-Fc is 0.05-0.3 μg/mL.
产品描述	IL-17 Protein, Rhesus, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 15.1 kDa and the accession number is A0A8J8YJF1.
种属	Rhesus
表达系统	Baculovirus Insect Cells
标签	Tag Free
蛋白编号	XP_001106391.1
别名	白细胞介素,白介素,interleukin 17A
蛋白构建	A DNA sequence encoding the rhesus IL17A (XP_001106391.1) (Met1-Ala155) was expressed. Predicted N terminal: Gly 24
蛋白纯度	> 95 % as determined by SDS-PAGE.
分子量	15.1 kDa (predicted)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tirs, 150 mM NaCl, pH 8.0, 10% glycerol. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy