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IL-31 Protein, Cynomolgus, Recombinant (N-His)

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产品编号 TMPY-05523U

IL-31 Protein, Cynomolgus, Recombinant (N-His) is expressed in HEK293 Cells. The accession number is G7PJ78-1.

IL-31 Protein, Cynomolgus, Recombinant (N-His)

一键复制产品信息

产品编号 TMPY-05523U

IL-31 Protein, Cynomolgus, Recombinant (N-His) is expressed in HEK293 Cells. The accession number is G7PJ78-1.

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产品信息

生物活性	Human IL-31 RA, hFc Tag captured on CM5 Chip via Protein A can bind Cynomolgus IL-31, His Tag with an affinity constant of 0.715 nM as determined in SPR assay (Biacore T200).
产品描述	IL-31 Protein, Cynomolgus, Recombinant (N-His) is expressed in HEK293 Cells. The accession number is G7PJ78-1.
种属	Cynomolgus
表达系统	HEK293 Cells
标签	N-His
蛋白编号	G7PJ78-1
别名	白细胞介素,白介素,interleukin 31
蛋白构建	Leu27-Thr163
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	16.5 kDa (Predicted); 23-30 kDa (Due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus. While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses. IL-31 was originally shown to be produced by activated helper T cells, particularly Th2 cells, mast cells, macrophages and dendritic cells.