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Interferon alpha 4/IFNA4 Protein, Human, Recombinant (hFc)

产品编号 TMPY-00829

别名: interferon, α4, IFN-α4a, 干扰素, interferon, alpha 4, MGC142200, IFN-alpha4a, INFA4

Interferon alpha 4/IFNA4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46 kDa and the accession number is P05014.

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Interferon alpha 4/IFNA4 Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 2,440		5日内发货

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参考文献

生物活性	Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV). The EC50 for this effect is 0.2-1 ng/mL.
产品描述	Interferon alpha 4/IFNA4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46 kDa and the accession number is P05014.

种属	Human
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	P05014
别名	interferon, α4, IFN-α4a, 干扰素, interferon, alpha 4, MGC142200, IFN-alpha4a, INFA4
蛋白构建	The mature form of Human IFN-α4a (NP_066546.1) (Cys 23-Asp 189) was expressed with the N-terminal fused Fc region of Human IgG1.
蛋白纯度	> 97 % as determined by SDS-PAGE
分子量	46 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Interferon, alpha 4 (IFNA4) belongs to the alpha/beta interferon family. Two variants of IFNA4 (IFNA4a and IFNA4b) are known, which differ from each other by changes in their coding regions at nucleotide positions 220 and 410 and can be distinguished by selective restriction enzyme analysis. Interferons are produced by macrophages, IFN-alpha has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. IFN-alpha, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. Originally discovered as an antiviral substance, the efficacy of IFN-alpha in malignant, viral, immunological, angiogenic, inflammatory, and fibrotic diseases suggests a spectrum of interrelated pathophysiologies. IFN-alpha emerged as a prototypic tumor suppressor protein that represses the clinical tumorigenic phenotype in some malignancies capable of differentiation.

参考文献

1. Lau JY,et al.(1993) Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet. 342(8881): 1208-9. 2. Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A. 91(4): 1198-205. 3. Kessler DS,et al.(1990) Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 4(10): 1753-65.

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Keywords

Interferon alpha 4/IFNA4 Protein, Human, Recombinant (hFc) interferon, α4 interferon, α 4 MGC-142200 INFA 4 IFN-α4a 干扰素 interferon, alpha 4 interferon, a 4 MGC 142200 MGC142200 IFN-alpha4a INFA4 INFA-4 recombinant recombinant-proteins proteins protein

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