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HGF Protein, Mouse, Recombinant (His)

产品编号 TMPY-03237

别名: SF/HGF, hepatocyte growth factor (hepapoietin A, 肝细胞生长因子, NK1, C230052L06Rik, scatter factor), HGF/SF, NK2, SF

HGF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80.8 kDa and the accession number is Q08048-1.

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HGF Protein, Mouse, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货
1 mg	￥ 19,500		5日内发货

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生物活性

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参考文献

生物活性	Measured by its ability to neutralize TGF-beta mediated inhibition on Mv-1-Lu cell proliferation. The ED50 for this effect is typically 1-8 ng/mL.
产品描述	HGF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80.8 kDa and the accession number is Q08048-1.

种属	Mouse
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q08048-1
别名	SF/HGF, hepatocyte growth factor (hepapoietin A, 肝细胞生长因子, NK1, C230052L06Rik, scatter factor), HGF/SF, NK2, SF
蛋白构建	Mouse HGF (Q08048-1) (Met1-Leu728)
蛋白纯度	> 70 % as determined by SDS-PAGE
分子量	80.8 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain, and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. The hepatocyte growth factor is secreted by mesenchymal cells as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility and matrix invasion give it a central role in angiogenesis, tumorogenesis, and tissue regeneration. HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF has no detectable protease activity. Defects in hepatocyte growth factor are the cause of deafness autosomal recessive type 39. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

参考文献

1. Naldini L,et al.(1991) Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 10(10):2867-78. 2. Comoglio,et al.(1993) Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. 65:131-65. 3. HAhn W,et al.(2011) Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model. The Journal of Gene Medicine. 13(10):549-55. 4. Bottaro DP,et al.(1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science. 251(4995):802-4.

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Keywords

HGF Protein, Mouse, Recombinant (His) SF/HGF hepatocyte growth factor (hepapoietin A 肝细胞生长因子 NK-1 NK1 C230052L06Rik scatter factor) NK-2 HGF/SF NK 1 NK2 NK 2 SF recombinant recombinant-proteins proteins protein

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