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HGF Protein, Mouse, Recombinant

HGF Protein, Mouse, Recombinant

产品编号 TMPY-03290
别名: hepatocyte growth factor (hepapoietin A, NK1, scatter factor), SF, 肝细胞生长因子, C230052L06Rik, SF/HGF, HGF/SF, NK2

HGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is Q08048-1.

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HGF Protein, Mouse, Recombinant
规格 价格/CNY 货期 数量
20 μg ¥ 1,350 现货
100 μg ¥ 5,430 5日内发货
200 μg ¥ 8,710 5日内发货
500 μg ¥ 16,220 5日内发货
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产品目录号及名称: HGF Protein, Mouse, Recombinant (TMPY-03290)
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生物活性
技术参数
产品性质
参考文献
生物活性 1. Immobilized mouse HGF at 10 μg/ml (100 μl/well) can bind mouse MET-Fc , EC50 of mouse MET-Fc is 0.05-0.12 μg/ml. 2. Measured by its ability to inhibit TGFß1 activity on Mv-1-lu mink lung epithelial cells. The ED50 for this effect is typically 1-4 ng/ml.

TargetMol Bioactive

产品描述 HGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is Q08048-1.
种属 Mouse
表达系统 HEK293 Cells
标签 Tag Free
蛋白编号 Q08048-1
别名 hepatocyte growth factor (hepapoietin A, NK1, scatter factor), SF, 肝细胞生长因子, C230052L06Rik, SF/HGF, HGF/SF, NK2
蛋白构建 The Mouse HGF (Q08048-1) (Met1-Leu728) was expressed and purified.
蛋白纯度 > 95 % as determined by SDS-PAGE

TargetMol

分子量 79.3 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain, and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. The hepatocyte growth factor is secreted by mesenchymal cells as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility and matrix invasion give it a central role in angiogenesis, tumorogenesis, and tissue regeneration. HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF has no detectable protease activity. Defects in hepatocyte growth factor are the cause of deafness autosomal recessive type 39. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

HGF Protein, Mouse, Recombinant hepatocyte growth factor (hepapoietin A NK1 scatter factor) NK 2 SF NK-1 肝细胞生长因子 C230052L06Rik NK 1 SF/HGF HGF/SF NK2 NK-2 recombinant recombinant-proteins proteins protein

 

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