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FOLR4/Juno Protein, Human, Recombinant (His)

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货号 TMPK-00585

别名 Juno, Izumo1r, FR-δ, FR-delta, FR δ, FR delta, FOLR4, LOC390243, Folbp3, Folate receptor 4

Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 25 kDa and the accession number is A6ND01-1.

FOLR4/Juno Protein, Human, Recombinant (His)
其他形式的 “FOLR4/Juno Protein, Human, Recombinant (His)”:
FOLR4/Juno Protein, Mouse, Recombinant (His)TMPK-01171
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FOLR4/Juno Protein, Human, Recombinant (His)

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Rating icon 还可以
SPR兼容缓冲液
货号 TMPK-00585 别名 Juno, Izumo1r, FR-δ, FR-delta, FR δ, FR delta, FOLR4, LOC390243, Folbp3, Folate receptor 4

Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 25 kDa and the accession number is A6ND01-1.

规格价格库存数量
5 μg
¥ 373
6-8日内发货
10 μg
¥ 598
6-8日内发货
20 μg
¥ 983
5日内发货
50 μg
¥ 1,930
5日内发货
100 μg
¥ 3,250
5日内发货
200 μg
¥ 5,890
5日内发货
500 μg
¥ 13,000
5日内发货
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产品介绍

生物活性
产品描述
Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 25 kDa and the accession number is A6ND01-1.
生物活性
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景
Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor.
种属
Human
表达系统
HEK293 Cells
标签C-His
蛋白编号A6ND01-1
蛋白构建Gly20-Ser228
蛋白纯度
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
蛋白性状Lyophilized powder
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名Juno, Izumo1r, FR-δ, FR-delta, FR δ, FR delta, FOLR4, LOC390243, Folbp3, Folate receptor 4
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量25 kDa (predicted). Due to glycosylation, the protein migrates to 30-35 kDa based on Tris-Bis PAGE result.
储存&溶解度
运输方式In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
存储

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剂量转换

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技术支持

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关键词

FOLR4, LOC-390243FOLR4, LOC 390243
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