FGF-14 Protein, Human, Recombinant (isoform 1B) is expressed in E. coli expression system. The predicted molecular weight is 21.1kDa and the accession number is Q92915-2.
生物活性 | Measured by its ability to bind human FGFR4-Fc in a functional ELISA. |
产品描述 | FGF-14 Protein, Human, Recombinant (isoform 1B) is expressed in E. coli expression system. The predicted molecular weight is 21.1kDa and the accession number is Q92915-2. |
种属 | Human |
表达系统 | E. coli |
标签 | Tag Free |
蛋白编号 | Q92915-2 |
别名 | SCA27, FHF-4, FGF-14, fibroblast growth factor 14, FHF4 |
蛋白构建 | The Human FGF14 isoform 1B (NP_787125.1) (Lys 64-Thr 252) was expressed and purified. |
蛋白纯度 | > 97 % as determined by SDS-PAGE |
分子量 | 21.1kDa (predicted) |
内毒素 | Please contact us for more information. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. |
研究背景 | FGF14 is a member of the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF14 is probably involved in nervous system development and function. Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27). It is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia. It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits. |
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FGF-14 Protein, Human, Recombinant (isoform 1B) SCA-27 FGF 14 SCA27 FHF-4 FGF-14 SCA 27 fibroblast growth factor 14 FHF 4 FHF4 FGF14 recombinant recombinant-proteins proteins protein