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DDR1 Protein, Mouse, Recombinant (His)

DDR1 Protein, Mouse, Recombinant (His)

产品编号 TMPY-02310
别名: CD167a, discoidin domain receptor tyrosine kinase 1, AI323681, Cak, 6030432F18, PTK3A, Nep

DDR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.4 kDa and the accession number is Q03146-1.

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DDR1 Protein, Mouse, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 5日内发货
1 mg ¥ 24,900 5日内发货
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产品目录号及名称: DDR1 Protein, Mouse, Recombinant (His) (TMPY-02310)
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生物活性 Testing in progress
产品描述 DDR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.4 kDa and the accession number is Q03146-1.
种属 Mouse
表达系统 HEK293 Cells
标签 C-His
蛋白编号 Q03146-1
别名 CD167a, discoidin domain receptor tyrosine kinase 1, AI323681, Cak, 6030432F18, PTK3A, Nep
蛋白构建 The extracellular domain of Mouse DDR1 (NP_766550.1) (Met 1-Thr 414) was expressed, with a C-terminal polyhistidine tag.
蛋白纯度 > 95 % as determined by SDS-PAGE
分子量 45.4 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.

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Keywords

DDR1 Protein, Mouse, Recombinant (His) CD167a discoidin domain receptor tyrosine kinase 1 AI 323681 AI323681 Cak AI-323681 6030432F18 PTK3A Nep recombinant recombinant-proteins proteins protein

 

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