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Claudin-4 Protein-VLP, Human, Recombinant

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货号 TMPK-00710

别名 WBSCR8, CPETR1, CPE-R, CPE R, CLDN4, Claudin-4, Claudin4

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.

Claudin-4 Protein-VLP, Human, Recombinant
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Claudin-4 Protein-VLP, Human, Recombinant

一键复制产品信息
Rating icon 还可以
SPR兼容缓冲液
货号 TMPK-00710 别名 WBSCR8, CPETR1, CPE-R, CPE R, CLDN4, Claudin-4, Claudin4

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.

规格价格库存数量
5 μg
¥ 1,080
6-8日内发货
10 μg
¥ 1,780
6-8日内发货
20 μg
¥ 2,970
5日内发货
50 μg
¥ 5,950
5日内发货
100 μg
¥ 10,300
5日内发货
200 μg
¥ 18,700
5日内发货
500 μg
¥ 41,500
5日内发货
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产品介绍


生物活性
产品描述
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
生物活性
Immobilized Human Claudin 4 VLP at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA.
研究背景
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
种属
Human
表达系统
HEK293 Cells
蛋白编号O14493
蛋白构建Met1-Val209
蛋白纯度
> 95% as determined by HPLC
蛋白性状Solution
缓冲液Supplied as 0.22 μm filtered solution in PBS (pH 7.4).Notice: If you need it for immunization, Do Not use any adjuvant.
别名WBSCR8, CPETR1, CPE-R, CPE R, CLDN4, Claudin-4, Claudin4
内毒素< 1 EU/μg by the LAL method.
化学信息
分子量23.31 kDa (predicted)
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.

计算器

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技术支持

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