CDK2 Protein, Human, Recombinant (E. coli, His)

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产品编号 TMPY-04542U

CDK2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. The accession number is P24941.

CDK2 Protein, Human, Recombinant (E. coli, His)

一键复制产品信息

产品编号 TMPY-04542U

CDK2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. The accession number is P24941.

规格	价格	库存
5 μg	¥ 585	6-8日内发货
10 μg	¥ 958	6-8日内发货
20 μg	¥ 1,590	5日内发货
50 μg	¥ 3,170	5日内发货
100 μg	¥ 5,560	5日内发货
200 μg	¥ 9,790	5日内发货
500 μg	¥ 20,800	5日内发货

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产品信息

生物活性	Activity has not been tested. It is theoretically active, but we cannot guarantee it.
产品描述	CDK2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. The accession number is P24941.
种属	Human
表达系统	E. coli
标签	N-6xHis
蛋白编号	P24941
别名	p33(CDK2),cyclin-dependent kinase 2,CDKN2
蛋白构建	Met1-Leu298
蛋白纯度	> 90% as determined by SDS-PAGE
分子量	36.1 kDa (Predicted); 34 kDa (Reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Solution
缓冲液	Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 200 mM NaCl, 1mM DTT, 40% Glycerol, pH 8.0.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Cyclin-dependent kinase 2 (CDK2) belongs to the cyclin-dependent kinase of Ser/Thr protein kinase. CDK2 acts as a catalytic subunit of the cyclin dependent kinase complex, whose activity is restricted to the G1-S phage of the cell cycle, it is essential for the G1/S transition. The kinase activity of CDK2 can be regulated by the association with a cyclin subunit, its phosphorylation state and CDK inhibitors. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Try14 and Tyr15. The inhibition of CDK2-cyclin complex can also be attributed to association with p27Kip1 and p21Waf1/Cip1. The activation of CDK2 has been shown to be necessary for apoptosis of quiescent cells, such as neurons, thymocytes and endothelial cells.