CD98 Protein, Mouse, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P10852-1.

Mouse

HEK293 Cells

solute carrier family 3 (amino acid transporter heavy chain), member 2,NACAE,Mgp-2hc,Mdu1,Ly-m10,Ly-10,Ly10,Cd98,AI314110,4F2HC,4F2

Ala100-Ala526

> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

The type II transmembrane protein CD98, best known as the heavy chain of the heterodimeric amino acid transporters (HAT), is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells. CD98 also interacts with beta1 integrins resulting in an increase in their affinity for ligand. In this study we explored the role of the transmembrane and cytoplasmic domains of CD98 on integrin-dependent cell adhesion and migration in polarized renal epithelial cells.