CD30L Protein, Human, Recombinant (hFc)

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SPR兼容缓冲液

货号 TMPY-00705

CD30L Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.8 kDa and the accession number is P32971.

CD30L Protein, Human, Recombinant (hFc)

一键复制产品信息

SPR兼容缓冲液

货号 TMPY-00705

CD30L Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.8 kDa and the accession number is P32971.

规格	价格	库存
5 μg	¥ 312	3日内发货
10 μg	¥ 496	3日内发货
20 μg	¥ 791	3日内发货
50 μg	¥ 1,570	3日内发货
100 μg	¥ 2,650	3日内发货
200 μg	¥ 4,470	现货

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产品信息

生物活性	Measured by its binding ability in a functional ELISA. Immobilized human CD30L-hFc at 2 μg/ml (100 μl/well) can bind human CD30/TNFRSF8-Fch , the EC50 of human CD30/TNFRSF8-Fch is 15-60 ng/mL.
产品描述	CD30L Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 47.8 kDa and the accession number is P32971.
种属	Human
表达系统	HEK293 Cells
标签	N-hFc
蛋白编号	P32971
别名	tumor necrosis factor (ligand) superfamily, member 8,CD30LG,CD30L,CD153
蛋白构建	A DNA sequence encoding the extracellular domain (Gln 63-Asp 234) of human CD30 Ligand (NP_001235.1) was fused with the Fc region of human IgG1 at the N-terminus. Predicted N terminal: Arg 23
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	47.8 kDa (predicted); 60-65 kDa (reducing condition, due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a membrane-associated glycoprotein belonging to the TNF superfamily and TNFR superfamily, and is a specific ligand for CD30/TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response. Thus, CD153 and its receptor CD30 are regarded as therapeutic targets in hematologic malignancies, autoimmune and inflammatory diseases.