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BMP-4 Protein, Human, Recombinant

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货号 TMPR-00001

别名 Bone morphogenetic protein 4, BMP-4, BMP4

BMP-4 Protein, Human, Recombinant is expressed in NS0 Cells. The accession number is Q53XC5.

BMP-4 Protein, Human, Recombinant

BMP-4 Protein, Human, Recombinant

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货号 TMPR-00001 别名 Bone morphogenetic protein 4, BMP-4, BMP4

BMP-4 Protein, Human, Recombinant is expressed in NS0 Cells. The accession number is Q53XC5.

规格价格库存数量
50 μg
¥ 22,800
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产品介绍

生物活性
产品描述
BMP-4 Protein, Human, Recombinant is expressed in NS0 Cells. The accession number is Q53XC5.
生物活性
Measured by its ability to induce BMP responsive SEAP reporter activity in HEK293 human embryonic kidney cells. The ED50 for this effect is 0.70-7.00 ng/mL.
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem. Biophys. Res. Commun. 315(2):272. The ED50 for this effect is 3.00-30.0 ng/mL.
研究背景
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling.
种属
Human
表达系统
Mouse myeloma cell line, NS0
标签Tag Free
蛋白编号Q53XC5
蛋白构建Ser293-Arg408, Disulfide-linked homodimer
蛋白纯度
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie Blue Staining.
蛋白性状Lyophilized powder
缓冲液Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
复溶方法Reconstitute at 50-200 μg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
别名Bone morphogenetic protein 4, BMP-4, BMP4
内毒素<0.01 EU per 1 μg of the protein by the LAL method.
化学信息
分子量19-24 kDa (reducing conditions); 35-41 kDa (non-reducing conditions)
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice.
存储It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

计算器

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剂量转换

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技术支持

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