VGB4 is an antagonist peptide of VEGF-A and VEGF-B, replicating the two binding regions of VEGF-B (loop 1 and loop 3) and connecting them through the receptor binding region of VEGF-A (loop 3). VGB4 displays significant anti-angiogenic and anti-tumor activities, capable of modulating tumor growth and metastasis through various mechanisms. It can be utilized in anti-cancer research.