规格

价格

库存

数量

1 mg

¥ 883

现货

2 mg

¥ 1,300

现货

生物活性

产品描述	UniPR129 is a highly selective, cell-permeable, competitive Eph/ephrin antagonist belonging to the class of L-tryptophan derivatives of lithocholic acid. UniPR129 inhibits the interaction between EphA2 and ephrin-A1 with an IC₅₀ of 945 nM and a Ki of 345 nM. UniPR129 inhibits angiogenesis in HUVEC cells with an IC₅₀ of 5.2 μM. UniPR129 exhibits antitumor and neuroprotective effects and can be used in research on cancer and neurological diseases.
靶点活性	EphA5:1.57 μM, EphA1:1.39 μM, EphA6:1.53 μM, EphB4:2.60 μM, EphB2:2.96 μM, EphB1:2.75 μM, EphA7:1.24 μM, EphA8:0.84 μM, EphA4:1.58 μM, EphB5:3.01 μM, EphA3:1.43 μM, EphB3:3.74 μM, EphA2:1.12 μM
体外活性	方法：人脐静脉内皮细胞(HUVEC)加入0–50 μM UniPR129 孵育1小时，然后接种于Matrigel，15小时后计数形成的多边形成熟管腔结构。结果：UniPR129有效抑制体外血管生成，IC₅₀ = 6.2 μM。[1]
体内活性	方法：为研究UniPR129的抗肿瘤效果，选用APC min/J小鼠 (C57BL6/J背景，雄性，5周龄) ，从5周龄开始口服给药 UniPR129 (30 mg/kg)，持续8周。结果：UniPR129处理使小鼠回肠腺瘤数量减少 42%，整体肠腺瘤数量减少 29%；腺瘤直径显著减小，且无大型/极大腺瘤出现。[2]
别名	UniPR-129, UniPR 129

化学信息

分子量	576.81
分子式	C₃₆H₅₂N₂O₄
CAS No.	1639159-47-9
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(N[C@@H](CC=5C=6C(NC5)=CC=CC6)CC(O)=O)=O)C)[H])[H]
密度	1.162 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: < 1?mg/mL?(insoluble)

DMSO: 26.66 mg/mL (46.22 mM), Sonication is recommended.

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

UniPR129