Tyrosylprotein Sulfotransferase 2 (TPST-2) is a subtype of TPST. Tyrosylprotein Sulfotransferase is a fully membrane-bound glycoprotein of the trans-Golgi network with a molecular weight of 54-50 kDa. It is found in nearly all tissues studied and catalyzes the tyrosine O-sulfation of soluble and membrane proteins passing through this compartment.