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TTX-080 是一种针对人白细胞抗原 G (HLA-G) 的首创 (First-in-class) 单克隆抗体,通过阻断 HLA-G 与其抑制性受体 (如 ILT2 和 ILT4) 的结合来发挥作用。该化合物是研究肿瘤免疫逃逸机制的重要工具,旨在通过解除 HLA-G 介导的检查点信号来恢复免疫细胞对恶性组织的杀伤效力。
TTX-080 是一种针对人白细胞抗原 G (HLA-G) 的首创 (First-in-class) 单克隆抗体,通过阻断 HLA-G 与其抑制性受体 (如 ILT2 和 ILT4) 的结合来发挥作用。该化合物是研究肿瘤免疫逃逸机制的重要工具,旨在通过解除 HLA-G 介导的检查点信号来恢复免疫细胞对恶性组织的杀伤效力。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 1 mg | ¥ 12,000 | 待询 | |
| 5 mg | 待询 | 待询 |
| 产品描述 | TTX-080 is a first-in-class monoclonal antibody targeting human leukocyte antigen G (HLA-G), acting by blocking the binding of HLA-G to its inhibitory receptors such as ILT2 and ILT4. The compound is an essential tool for investigating tumor immune escape mechanisms, aiming to restore the killing efficacy of immune cells against malignant tissues by lifting the HLA-G-mediated checkpoint signaling. |
| 反应种属 | Human |
| 应用 | ELISA FACS Functional assay |
| 抗体种类 | Monoclonal |
| 缓冲液 | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| 内毒素 | <1.0 EU/mg |
| 同型 | IgG1-LALA-GA-EM |
| 偶联 | Unconjugated |
| Uniprot ID | |
| 靶点 | HLA-G |
| 存储 | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
对于不同动物的给药剂量换算,您也可以参考 更多