'R-(+)-Sibutramine ((+)-Sibutramine) administered orally at doses of 0-20 mg/kg demonstrates an anorexic effect in Wistar albino rats weighing 300-400 g, regardless of sex [1]. The substance was given once, with doses including 5, 10, and 20 mg/kg. The results indicated a more pronounced anorexic effect compared to its racemic mixture (RS)-sibutramine and the (S)-enantiomers.'