QND8 is a selective and potent agonist of the α7 nicotinic acetylcholine receptor (nAChR). It alleviates thermal hyperalgesia and mechanical allodynia in carrageenan-induced inflammatory pain in mice. QND8 also reduces paw swelling, inhibits the release of pro-inflammatory factors at inflammation sites, and prevents leukocyte infiltration. It is applicable in research on inflammatory and neurological diseases, like arthritis.