PMEG-DP disodium is an effective inhibitor of DNA polymerase (IC50=2.5 μM), exerting strong inhibitory effects particularly on DNA polymerases α and δ. As the active metabolite of GS-9191, it efficiently impedes the growth of cell lines infected with human papillomavirus (HPV). PMEG-DP disodium is useful in research related to HPV-associated diseases.