P2Y1 antagonist 2 (Compound 19) is a P2Y1 receptor antagonist with an IC50 of 0.49 μM. It exhibits significant anti-platelet aggregation activity by inhibiting the P2Y1 receptor. Additionally, this compound elevates nuclear Nrf2 protein levels, showing neuroprotective effects against oxidative stress damage. P2Y1 antagonist 2 effectively reduces cerebral infarction size and improves neurological function, making it useful for ischemic stroke research.