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顶部相关产品产品介绍化学信息储存和溶解信息计算器

N-3-oxo-tetradecanoyl-L-Homoserine lactone

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货号 T37339Cas号 177158-19-9

别名 N-3-oxo-tetradecanoyl-L-Homoserine lactone, N-3-oxo-myristoyl-L-Homoserine lactone, 3-oxo-C14-HSL

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-3-oxo-tetradecanoyl-L-homoserine lactone (3-oxo-C14-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria.[1] [2] [3] It appears later than shorter acyl chain AHLs in developing biofilms [4] and, like other long chain 3-oxo-AHLs, stimulates the production of putisolvin, [5] which in turn, inhibits biofilm formation.

N-3-oxo-tetradecanoyl-L-Homoserine lactone

N-3-oxo-tetradecanoyl-L-Homoserine lactone

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货号 T37339 别名 N-3-oxo-tetradecanoyl-L-Homoserine lactone, N-3-oxo-myristoyl-L-Homoserine lactone, 3-oxo-C14-HSLCas号 177158-19-9

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-3-oxo-tetradecanoyl-L-homoserine lactone (3-oxo-C14-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria.[1] [2] [3] It appears later than shorter acyl chain AHLs in developing biofilms [4] and, like other long chain 3-oxo-AHLs, stimulates the production of putisolvin, [5] which in turn, inhibits biofilm formation.

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2 mg
¥ 1,920
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Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by the synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-3-oxo-tetradecanoyl-L-homoserine lactone (3-oxo-C14-HSL) is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria.[1] [2] [3] It appears later than shorter acyl chain AHLs in developing biofilms [4] and, like other long chain 3-oxo-AHLs, stimulates the production of putisolvin, [5] which in turn, inhibits biofilm formation.
别名N-3-oxo-tetradecanoyl-L-Homoserine lactone, N-3-oxo-myristoyl-L-Homoserine lactone, 3-oxo-C14-HSL
化学信息
分子量325.44
分子式C18H31NO4
CAS No.177158-19-9
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 20 mg/mL (61.46 mM), Sonication is recommended.
DMF: 20 mg/mL (61.46 mM), Sonication is recommended.
Ethanol: 10 mg/mL (30.73 mM), Sonication is recommended.
体内实验配方
10% DMSO+90% Corn Oil: 2 mg/mL (6.15 mM), Sonication is recommeded.
请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。
溶液配制表
Ethanol/DMSO/DMF
1mg5mg10mg50mg
1 mM3.0728 mL15.3638 mL30.7276 mL153.6382 mL
5 mM0.6146 mL3.0728 mL6.1455 mL30.7276 mL
10 mM0.3073 mL1.5364 mL3.0728 mL15.3638 mL
20 mM0.1536 mL0.7682 mL1.5364 mL7.6819 mL
DMSO/DMF
1mg5mg10mg50mg
50 mM0.0615 mL0.3073 mL0.6146 mL3.0728 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O ， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

N 3 oxo tetradecanoyl L Homoserine lactoneN3oxotetradecanoylLHomoserine lactone
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