Name: MGTA-117 Antibody
Brand: TargetMol
SKU: T9901A-1080
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 12,000

待询

5 mg

待询

生物活性

产品描述	MGTA-117 is a humanized monoclonal antibody that targets CD117. It carries an amanitin payload and is used to synthesize antibody-drug conjugates (ADC). MGTA-117 demonstrates potent antitumor activity, enhancing survival in three acute myeloid leukemia (AML) xenograft models [Kasumi-1, AML PDX 1, and AML PDX 2]. It is applicable for AML, myelodysplastic syndromes with excess blasts (MDS-EB), and preconditioning for hematopoietic stem cell transplantation (HSCT) in gene therapy.
体外活性	MGTA-117 (0.1-1.0 mg/kg) 能快速选择性地结合并清除CD117+细胞（人类造血干细胞和AML肿瘤细胞），其IC 50 均小于10 pM。MGTA-117 在AML小鼠模型中能够有效清除超过95%的人类造血祖细胞 (HSPCs)。
体内活性	MGTA-117 (0.1 mg/kg, i.v., once for 21 days) 在人源化 NSG (hNSG) 小鼠中具有91小时的短半衰期，能选择性清除≥95%的HSPCs。MGTA-117 (3及10 mg/kg，用一次或3 mg/kg，每隔一天用两次) 在Kasumi-1异种移植hNSG小鼠模型中显着提高生存率2.4-2.7倍。MGTA-117 (3及10 mg/kg，用一次) 在AML PDX 1 (提高生存率2-3.3倍) 和AML PDX 2 (提高生存率1.3-1.8倍) 异种移植hNSG小鼠模型中显著减少外周肿瘤负担，延缓肿瘤生长，并提高生存率。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
内毒素	＜ 1.0 EU/mg

偶联与修饰

偶联	Unconjugated

储存&溶解度

存储	store at low temperature \| -20°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

MGTA-117 Antibody