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MEDI-570 是一种在CHO细胞中表达的人源化IgG1单克隆抗体,靶向诱导型T细胞共刺激分子 (ICOS/CD278)。该抗体作为强效的激动剂,能高亲和力结合ICOS受体,模拟并增强其天然配体ICOS-L的共刺激信号。这种激动作用促进T细胞(包括效应T细胞和T滤泡辅助细胞)的活化、增殖、存活及细胞因子分泌。它被开发为一种癌症免疫治疗剂,旨在通过增强T细胞功能来对抗肿瘤。
MEDI-570 是一种在CHO细胞中表达的人源化IgG1单克隆抗体,靶向诱导型T细胞共刺激分子 (ICOS/CD278)。该抗体作为强效的激动剂,能高亲和力结合ICOS受体,模拟并增强其天然配体ICOS-L的共刺激信号。这种激动作用促进T细胞(包括效应T细胞和T滤泡辅助细胞)的活化、增殖、存活及细胞因子分泌。它被开发为一种癌症免疫治疗剂,旨在通过增强T细胞功能来对抗肿瘤。

| 产品描述 | MEDI-570 is a humanized IgG1 monoclonal antibody produced in CHO cells, targeting the inducible T-cell costimulator (ICOS/CD278). Functioning as a potent agonist, it binds with high affinity to the ICOS receptor, mimicking and amplifying the costimulatory signal of its natural ligand, ICOS-L. This agonistic activity promotes the activation, proliferation, survival, and cytokine production of T cells, including effector T cells and T follicular helper (Tfh) cells. It is developed as a cancer immunotherapeutic agent designed to combat tumors by enhancing T-cell function. |
| 反应种属 | Human |
| 应用 | ELISA FACS Functional assay |
| 抗体种类 | Monoclonal |
| 缓冲液 | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| 内毒素 | <1.0 EU/mg |
| 同型 | IgG1 |
| 偶联 | Unconjugated |
| Uniprot ID | |
| 靶点 | ICOS/CD278 |
| CAS No. | 2179209-59-5 |
| 存储 |
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